NanoViricides Reports Sustained Anti-HIV Effect with Much Shorter Drug Dosing than HAART Drug Cocktail

WEST HAVEN, CONNECTICUT -- August 15, 2011 -- NanoViricides, Inc. (OTC BB: NNVC) (the "Company") reports that its lead anti-HIV candidate achieved a long term anti-HIV effect with a much shorter dosing regimen and a markedly lower total drug dose than that of the HAART Drug Cocktail therapy. Treatment with the lead anti-HIV nanoviricide reduced HIV levels and protected the human T cells (CD4+,CD8+) to the same extent as treatment with the HAART cocktail in the SCID/hu Thy/Liv mouse model. The three drug HAART cocktail used for comparison in this study is one of the combination therapies recommended for initial therapy in humans, AZT, 3TC and Efavirenz. Other specific results of this study were recently announced by the Company.

The nanoviricide agent was dosed 8 times in the first 20 days after HIV infection whereas the HAART cocktail was dosed daily for the 48 day study duration. The nanoviricide total dose was 1,200 mg/kg while the HAART cocktail dose was 4,800 mg/kg. At both 24 and 48 days after HIV infection, the HIV viral load was markedly reduced to the same extent in both the NNVC-treated mice and the HAART-treated mice and the “double positive”, CD4+,CD8+, human T cells were similarly protected in both treatment groups. Thus, 28 days, roughly 1 month, after stopping nanoviricide dosing, the clinical benefit on HIV viral load and T cells was sustained.

The Company believes that achieving this sustained clinical benefit after stopping nanoviricide treatment is highly significant. In a previous influenza virus study, a similar sustained reduction in viral load was observed. This supports the NanoViricides anti-viral mechanisms. It is important to emphasize that mouse drug metabolism is much faster than human metabolism. Thus, if nanoviricide therapy is effective in HIV-infected humans, a sustained clinical benefit can be envisioned with intermittent nanoviricide treatment.

"It's been more than 30 years since I saw my first patient who turned out to have HIV/AIDS," said Eugene Seymour, MD, MPH, CEO, "since then I've always dreamt of the day a drug like ours would come along. Studies using our current HIVCide™ candidate in the standard HIV drug test model resulted in extensive destruction of the virus, defined as a "functional cure." Human testing must be done to confirm our hypothesis that this drug can be administered infrequently to maintain a functional cure.  I feel this could be as infrequently as monthly or every other month. If confirmed, this would be the biggest advance in HIV/AIDS therapy since the advent of protease inhibitors fifteen years ago."

The study was performed at KARD Scientific, Inc., Beverly, MA, in a Bio-Safety Level 3 (BSL-3) facility under the guidance of Dr. Krishna Menon who has extensive experience in pre-clinical evaluation of drug candidates in disease-relevant animal models.

About NanoViricides : NanoViricides, Inc. ( is a development stage company that is creating special purpose nanomaterials for antiviral therapy. The Company's novel nanoviricide® class of drug candidates are designed to specifically attack enveloped virus particles and to dismantle them. The Company is developing drugs against a number of viral diseases including H1N1 swine flu, H5N1 bird flu, seasonal Influenza, HIV, oral and genital Herpes, viral diseases of the eye including EKC and herpes keratitis, Hepatitis C, Rabies, Dengue fever, and Ebola virus, among others. This press release contains forward-looking statements that reflect the Company's current expectation regarding future events. Actual events could differ materially and substantially from those projected herein and depend on a number of factors. Certain statements in this release, and other written or oral statements made by NanoViricides, Inc. are "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. You should not place undue reliance on forward-looking statements since they involve known and unknown risks, uncertainties and other factors which are, in some cases, beyond the Company's control and which could, and likely will, materially affect actual results, levels of activity, performance or achievements. The Company assumes no obligation to publicly update or revise these forward-looking statements for any reason, or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if new information becomes available in the future. Important factors that could cause actual results to differ materially from the company's expectations include, but are not limited to, those factors that are disclosed under the heading "Risk Factors" and elsewhere in documents filed by the company from time to time with the United States Securities and Exchange Commission and other regulatory authorities.  Although it is not possible to predict or identify all such factors, they may include the following: demonstration and proof of principle in preclinical trials that a nanoviricide is safe and effective; successful development of our product candidates; our ability to seek and obtain regulatory approvals, including with respect to the indications we are seeking; the successful commercialization of our product candidates; and market acceptance of our products.

NanoViricides, Inc.
Amanda Schuon, 310-550-7200